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HRID870927

反应详情

EQUATION

反应方程式

HRID 870927 的结构方程式

REACTANTS

反应物

2
反应SMILES：CC(C)C[C@@H](CO)NC(=O)OC(C)(C)C
HCID7018766

Boc-L-leucinol

C11H23NO3

反应SMILES：CC(=O)Nc1nccc2c1C(C)Oc1cc(Cl)ccc1-2
HCID86724433

未命名化合物

PRODUCTS

产物

1
反应SMILES：CC(=O)Nc1nccc2c1C(C)Oc1cc(OC[C@H](CC(C)C)NC(=O)OC(C)(C)C)ccc1-2
HCID86724432

未命名化合物

收率 51%

PROCEDURE

实验过程

Prepared as described in Example 8, Part C using (S)-tert-butyl (1-hydroxy-4-methylpentan-2-yl)carbamate and N-(8-chloro-5-methyl-5H-chromeno[3,4-c]pyridin-4-yl)acetamide to afford tert-butyl ((2S)-1-((4-acetamido-5-methyl-5H-chromeno[3,4-c]pyridin-8-yl)oxy)-4-methylpentan-2-yl)carbamate (0.6 g, 0.882 mmol, 51% yield) as a yellow solid. LCMS (ESI) m/e 470.2 [(M+H)+, calcd for C26H36N3O5 470.3]; LC/MS retention time (Method C): tR=1.89 min.

WORKUP

后处理

  1. customPrepared