反应详情

The title compound was prepared as in Example 1 starting from morpholine and 5-{2-[5-(3,4-dichlorophenyl)furan-2-yl]ethylcarbamoyl}-1H-pyrazole-3-carboxylic acid. Crude product was purified by chromatography (CombiFlash, 1st column silica, eluent: 0-10% MeOH/DCM: 2nd column C-18 RP, eluent: 0-100% MeCN/water) to give 505 mg (17%) of the title compound. 1H-NMR (400 MHz; d6-DMSO): δ 2.95 (t, 1H), 3.56 (q, 1H), 3.62 (br s, 6H), 3.90 (br s, 2H), 6.34 (d, 1H), 7.02 (d, 1H), 7.08 (s, 1H), 7.62 (m, 2H), 7.85 (d, 1H), 8.61 (s, 1H), 13.94 (s, 1H).

1. customCrude product was purified by chromatography (CombiFlash, 1st column silica, eluent: 0-10% MeOH/DCM: 2nd column C-18 RP, eluent: 0-100% MeCN/water)