2-(3-(2-Methoxy-4-nitrophenyl)-1H-pyrazol-1-yl)ethanamine → HCID 178493299, compound

HRID 872483Notes

Reaction equation

HRID 872483 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([N+:9]([O-:11])=[O:10])[CH:6]=[CH:5][C:4]=1[C:12]1[CH:16]=[CH:15][N:14]([CH2:17][CH2:18][NH2:19])[N:13]=1.[O:20]1[CH:24]=[CH:23][CH:22]=[C:21]1[C:25]1[CH:29]=[C:28]([C:30](O)=[O:31])[NH:27][N:26]=1>>[O:20]1[CH:24]=[CH:23][CH:22]=[C:21]1[C:25]1[CH:29]=[C:28]([C:30]([NH:19][CH2:18][CH2:17][N:14]2[CH:15]=[CH:16][C:12]([C:4]3[CH:5]=[CH:6][C:7]([N+:9]([O-:11])=[O:10])=[CH:8][C:3]=3[O:2][CH3:1])=[N:13]2)=[O:31])[NH:27][N:26]=1

Participants

3

Reactant 2

HCID 671729732-(3-(2-Methoxy-4-nitrophenyl)-1H-pyrazol-1-yl)ethanamineHCID 178524128HCID 178524128, compound

Product 1

HCID 178493299HCID 178493299, compound

Procedure

The title compound was prepared from 2-(3-(2-Methoxy-4-nitrophenyl)-1H-pyrazol-1-yl)ethanamine (0.11 g) and 3-(furan-2-yl)-1H-pyrazole-5-carboxylic acid (0.079 g) using the method of Example 34(d). Yield 0.11 g. 1H-NMR (400 MHz; d6-DMSO): δ 3.71 (t, 2H), 4.01 (s, 3H), 4.39 (t, 2H), 6.57-6.68 (m, 2H), 6.85-6.89 (m, 2H), 7.76-7.93 (m, 4H), 8.15-8.22 (m, 1H), 8.53 (br s, 1H), 13.71 (br s, 1H).

Sources & evidence

ORD record
ord-9c42baf105514de38bcc102b92f4545c
Source dataset
uspto-grants-2015_03
Patent number
US08975254B2

Reaction notes

Loading…