HRID872860

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(O[Si](c1ccccc1)(c1ccccc1)C(C)(C)C)c1nc(C(=O)O)cs1

HCID67168375

未命名化合物

结构：C[C@H](N)Cn1ccc(-c2ccc(C#N)c(Cl)c2)n1

HCID67170882

4-[1-[(2S)-2-Aminopropyl]-1H-pyrazol-3-yl]-2-chlorobenzonitrile

C13H13ClN4

PRODUCTS

生成物

结构：CC(O[Si](c1ccccc1)(c1ccccc1)C(C)(C)C)c1nc(C(=O)N[C@@H](C)Cn2ccc(-c3ccc(C#N)c(Cl)c3)n2)cs1

HCID70654132

未命名化合物

PROCEDURE

实验过程

The title compound was prepared using the method of Example 34(d) starting from 2-(1-(tert-butyldiphenylsilyloxy)ethyl)thiazole-4-carboxylic acid (326 mg, 0.792 mmol) and (S)-4-(1-(2-aminopropyl)-1H-pyrazol-3-yl)-2-chlorobenzonitrile (105 mg, 0.403 mmol). After extraction, based on the LC-MS data, the product was estimated to be pure enough for the next step. LC-MS: [M+1]=655.30.

WORKUP

后处理

extractionAfter extraction

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-80208f31bbab458dbd2dd6ac0634548a
来源数据集: uspto-grants-2015_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08975254B2
来源说明: uspto-grants-2015_03

反应 SMILES

[Si:1]([O:18][CH:19]([C:21]1[S:22][CH:23]=[C:24]([C:26]([OH:28])=O)[N:25]=1)[CH3:20])([C:14]([CH3:17])([CH3:16])[CH3:15])([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH2:29][C@@H:30]([CH3:46])[CH2:31][N:32]1[CH:36]=[CH:35][C:34]([C:37]2[CH:44]=[CH:43][C:40]([C:41]#[N:42])=[C:39]([Cl:45])[CH:38]=2)=[N:33]1>>[Si:1]([O:18][CH:19]([C:21]1[S:22][CH:23]=[C:24]([C:26]([NH:29][C@@H:30]([CH3:46])[CH2:31][N:32]2[CH:36]=[CH:35][C:34]([C:37]3[CH:44]=[CH:43][C:40]([C:41]#[N:42])=[C:39]([Cl:45])[CH:38]=3)=[N:33]2)=[O:28])[N:25]=1)[CH3:20])([C:14]([CH3:17])([CH3:15])[CH3:16])([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1