反应详情

The title compound was prepared as described in Example 1, substituting (S)-1-((benzyloxy)carbonyl)pyrrolidine-3-carboxylic acid for 1-(benzyloxycarbonyl)azetidine-3-carboxylic acid and tert-butyl 4-(4-aminophenyl)piperidine-1-carboxylate for tert-butyl 4-(4-aminophenoxy)piperidine-1-carboxylate in Example 1A, and cyclopentylbenzoic acid for 2-(tetrahydro-2H-pyran-4-yl)acetic acid in Example 1E. 1H NMR (300 MHz, DMSO-d6) δ ppm 10.03 (s, 1H), 7.95 (d, J=2.8 Hz, 1H), 7.85 (dd, J=4.6, 1.2 Hz, 1H), 7.55 (t, J=10.1 Hz, 2H), 7.16 (dd, J=8.3, 4.3 Hz, 3H), 6.92 (ddd, J=8.4, 2.9, 1.3 Hz, 1H), 4.54 (d, J=12.7 Hz, 1H), 3.98 (d, J=13.7 Hz, 1H), 3.64-3.48 (m, 1H), 3.48-3.38 (m, 1H), 3.22-2.87 (m, 2H), 2.68 (dd, J=24.3, 12.3 Hz, 1H), 2.41-2.01 (m, 6H), 1.77 (s, 4H), 1.68-1.04 (m, 9H); MS (ESI(+)) m/e 461 (M+H)+.