反应详情

The title compound was prepared as described in Example 1C, substituting 4-bromopyridazine for 3-bromopyridine and (S)-5-(1-isobutyl-1H-pyrazol-4-yl)-N-(pyrrolidin-3-yl)thiophene-2-carboxamide for tert-butyl 4-(4-(azetidine-3-carboxamido)phenoxy)piperidine-1-carboxylate. 1H NMR (300 MHz, DMSO-d6) δ ppm 0.75-0.98 (m, 6 H) 1.98-2.44 (m, 3 H) 3.67-4.18 (m, 6 H) 4.66 (s, 1 H) 7.15 (dd, J=7.12, 3.05 Hz, 1 H) 7.21 (d, J=3.73 Hz, 1 H) 7.54-7.91 (m, 2 H) 8.14 (s, 1 H) 8.56-8.95 (m, 3 H); MS (ESI(+)) m/e 397 (M+H)+.