反应详情

The title compound was prepared in analogy to the procedure described in Step 112.5 using 4-(4-chlorophenyl)-3-cyclopropyl-5-(3,8-dimethyl-[1,2,4]triazolo[4,3-a]pyridin-6-yl)-4,5-dihydropyrrolo[3,4-c]pyrazol-6(1H)-one (Step 129.1) and MeI at RT for 30 min. The crude product was purified by preparative achiral SFC (column NH2, gradient 19-24% in 6 min_total 11 min). tR: 0.95 min (LC-MS 2); ESI-MS: 433.2 [M+H]+ (LC-MS 2); 1H NMR (400 MHz, DMSO-d6) δ ppm-0.10-0.07 (m, 1H) 0.50-0.78 (m, 3H) 1.59-1.76 (m, 1H) 1.92 (s, 3H) 3.36 (s, 3H) 3.92 (s, 3H) 6.09 (s, 1H) 7.27 (d, J=8.4 Hz, 2H) 7.32-7.45 (m, 3H) 7.68 (d, J=2.7 Hz, 1H).

1. customThe crude product was purified by preparative achiral SFC (column NH2, gradient 19-24% in 6 min_total 11 min)