HRID874879

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID75071

2-Amino-6-chlorobenzoic acid

C7H6ClNO2

HCID151210

6-Methylanthranilic acid

C8H9NO2

结构：CC(C)(C)OCC(NC(=O)OCc1ccccc1)C(=O)ON1C(=O)CCC1=O

HCID2729196

未命名化合物

结构：CCC(NC(=O)OCc1ccccc1)C(=O)ON1C(=O)CCC1=O

HCID12961228

未命名化合物

结构：CCC(Nc1ncnc2[nH]cnc12)c1nc2cccc(C)c2c(=O)n1-c1ccccc1

HCID178456854

未命名化合物

PRODUCTS

生成物

结构：CC(C)(C)OCC(Nc1ncnc2[nH]cnc12)c1nc2ccccc2c(=O)n1-c1ccccc1

HCID178450505

未命名化合物

PROCEDURE

实验过程

2-[2-tert-butoxy-1-(9H-purin-6-ylamino)ethyl]-3-phenyl-3H-quinazolin-4one was prepared using the general procedure described above with respect to compound 14, but 2-amino-6-chlorobenzoic acid was substituted for 2-amino-6-methylbenzoic acid in step A, 2-benzyloxycarbonylamino-3-tert-butoxy-propionic acid 2,5-dioxo-pyrrolidin-1-yl ester was substituted for 2-benzyloxycarbonylaminobutyric acid 2,5-dioxo-pyrrolidin-1-yl ester in step B, and the conditions used in step C removed both the benzyl protecting group and the A-Ring chloro substituent.

WORKUP

后处理

customremoved both the benzyl protecting group

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-d2fc2196c5f24e6894ac4c553430f792
来源数据集: uspto-grants-2015_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08980901B2
来源说明: uspto-grants-2015_03

反应 SMILES

C[C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[C:4](=[O:31])[N:5]([C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1)[C:6]([CH:12]([NH:15][C:16]1[N:24]=[CH:23][N:22]=[C:21]3[C:17]=1[N:18]=[CH:19][NH:20]3)CC)=[N:7]2.NC1C=CC=C(Cl)C=1C(O)=O.NC1C=CC=C(C)C=1C(O)=O.O=C1CCC(=O)N1OC(=O)C(NC(OCC1C=CC=CC=1)=O)[CH2:64][O:65][C:66]([CH3:69])([CH3:68])[CH3:67].O=C1CCC(=O)N1OC(=O)C(NC(OCC1C=CC=CC=1)=O)CC>>[C:66]([O:65][CH2:64][CH:12]([C:6]1[N:5]([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)[C:4](=[O:31])[C:3]2[C:8](=[CH:9][CH:10]=[CH:11][CH:2]=2)[N:7]=1)[NH:15][C:16]1[N:24]=[CH:23][N:22]=[C:21]2[C:17]=1[N:18]=[CH:19][NH:20]2)([CH3:69])([CH3:68])[CH3:67]