1-(Pyridin-3-yl)piperazine → HCID 53327907, compound

HRID 875012Notes

Reaction equation

HRID 875012 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([N:7]2[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]2)[CH:2]=1.[F:13][C:14]([F:30])([F:29])[C:15]1[O:19][N:18]=[C:17]([C:20]2[CH:21]=[C:22]([CH:26]=[CH:27][CH:28]=2)[C:23](O)=[O:24])[N:16]=1>>[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([N:7]2[CH2:8][CH2:9][N:10]([C:23]([C:22]3[CH:26]=[CH:27][CH:28]=[C:20]([C:17]4[N:16]=[C:15]([C:14]([F:29])([F:13])[F:30])[O:19][N:18]=4)[CH:21]=3)=[O:24])[CH2:11][CH2:12]2)[CH:2]=1

Participants

3

Reactant 2

HCID 4372341-(Pyridin-3-yl)piperazineHCID 251808543-(5-(Trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzoic acid

Product 1

HCID 53327907HCID 53327907, compoundYield 47%

Procedure

This compound was synthesized from 1-(pyridin-3-yl)piperazine and 3-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzoic acid as described for example 37 step 3 (110 mg, yield 47%). 1H NMR (400 MHz, DMSO-d6) δ 8.32-8.31 (m, 1H), 8.18-8.15 (dt, J=6.7 Hz, 2.0 Hz, 1H), 8.08 (m, 1H), 8.03-8.02 (m, 1H), 7.76-7.71 (m, 2H), 7.36-7.33 (ddd, J=8.5 Hz, 3.0 Hz, 1.2 Hz, 1H), 7.25-7.22 (m, 1H), 3.81 (m, 2H), 3.50 (m, 2H), 3.21 (m, 4H). MS (ESI) m/z: Calculated for C19H16F3N6O2: 403.13. found: 404.2 (M+H)+

Sources & evidence

ORD record
ord-061042542a0e4179b93651c91f96aaf4
Source dataset
uspto-grants-2015_03
Patent number
US08981084B2

Reaction notes

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