反应详情

This compound was synthesized from tert-butyl piperazine-1-carboxylate and 2-(4-fluorophenyl)oxazole-4-carbaldehyde as described for example 82 step 3 (240 mg, yield 42%). 1H NMR (400 MHz, CDCl3) δ 8.07-8.03 (dd, J=9.1 Hz, 5.3 Hz, 2H), 7.59 (s, 1H), 7.16-7.12 (t, J=8.8 Hz, 2H), 3.54 (s, 2H), 3.49-3.47 (m, 4H), 2.52-2.49 (m, 4H), 1.46 (s, 9H). MS (ESI) m/z: Calculated for C19H24FN3O3: 361.18. found: 362.2 (M+H)+