反应详情

A solution of N-[4-(2-benzyloxy-4-fluoro-phenyl)-pyridin-3-yl]-N-methyl-3,5-bis-trifluoromethyl-benzamide (65 mg, 0.118 mmol, example 43) in MeOH (10 mL) was purged with argon for 20 minutes before 10% Pd—C (10 mg) was added. The resulting reaction mixture was hydrogenated under balloon pressure hydrogen at 25° C. for 16 hours. The reaction mixture was filtered through a bed of celite and the residue was further washed with EtOAc. The combined filtrate was concentrated in vacuo, and the crude material thus obtained was purified by column chromatography over silica gel (25-35% EtOAc in n-hexane) to give 45 mg of the desired compound. Off-white solid (60%). MS (ESI): m/z=459.0 [M+H]+.

1. additionwas added
2. customThe resulting reaction mixture
3. filtrationThe reaction mixture was filtered through a bed of celite
4. washthe residue was further washed with EtOAc
5. concentrationThe combined filtrate was concentrated in vacuo
6. customthe crude material thus obtained
7. customwas purified by column chromatography over silica gel (25-35% EtOAc in n-hexane)