反应详情

The title compound was prepared in analogy to Example 90, from [6-chloro-4-(4-fluoro-2-methoxy-phenyl)-pyridin-3-yl]-methyl-amine and 3-methanesulfonyl-5-trifluoromethyl-benzoic acid (example 114, intermediate a) after a reaction time of 17 hours. The compound was purified by silica gel chromatography using an MPLC (ISCO) system eluting with a gradient of n-heptane:EtOAc (100:0 to 50:50). The volatiles were evaporated until a precipitate formed. The suspension was filtered and the filter cake was washed three times with a small amount of a mixture of EtOAc:n-heptane (1:4) to give the title compound as a colorless solid (61%). MS (ESI): m/z=517.06 [M+H]+.

1. customThe compound was purified by silica gel chromatography
2. washeluting with a gradient of n-heptane:EtOAc (100:0 to 50:50)
3. customThe volatiles were evaporated until a precipitate
4. customformed
5. filtrationThe suspension was filtered
6. washthe filter cake was washed three times
7. additionwith a small amount of a mixture of EtOAc:n-heptane (1:4)