反应详情

The title compound was prepared in analogy to example 90, from [6-chloro-4-(5-fluoro-2-methyl-phenyl)-pyridin-3-yl]-methyl-amine and 3-(methylsulfonyl)-5-(trifluoromethyl)benzoic acid (example 114, intermediate a) after a reaction time of 64 hours. The compound was purified by silica gel chromatography on a 20 g column using an MPLC (ISCO) system eluting with a gradient of n-heptane:EtOAc (100:0 to 20:80). The product was further purified by preparative HPLC (Gemini NX column) using a gradient of MeOH:water (containing 0.1% formic acid) (20:80 to 98:2). Colorless foam (5%). MS (ESI): m/z=501.07 [M+H]+.

1. customThe compound was purified by silica gel chromatography on a 20 g column
2. washeluting with a gradient of n-heptane:EtOAc (100:0 to 20:80)
3. customThe product was further purified by preparative HPLC (Gemini NX column)