反应详情

The title compound was prepared in analogy to example 90, from 4-(2-chlorophenyl)-N-(2,2,2-trifluoroethyl)pyridin-3-amine and 3-(methylsulfonyl)-5-(trifluoromethyl)benzoic acid (example 114, intermediate a) after a reaction time of 18 hours at room temperature. The compound was purified by silica gel chromatography on a 20 g column using an MPLC (Flashmaster) system eluting with a gradient of n-heptane:EtOAc (100:0 to 0:100). Further purification by preparative HPLC (Gemini NX) with a gradient of MeOH:water (containing 0.05% formic acid) (80:20 to 98:2). Colorless solid (31%). MS (ESI): m/z=537.045 [M+H]+.

1. customThe compound was purified by silica gel chromatography on a 20 g column
2. washeluting with a gradient of n-heptane:EtOAc (100:0 to 0:100)
3. customFurther purification by preparative HPLC (Gemini NX) with a gradient of MeOH