反应详情

In a mixture of 2.3 g of 40% methylamine aqueous solution and 10 mL of tetrahydrofuran, a solution of 1.0 g of 4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]-2-methylbenzoyl-chloride synthesized in Step 4 of Synthetic Example 1 in 10 mL of tetrahydrofuran was added dropwise under cooling with ice and with stirring. After the completion of the addition dropwise, it was continued to stir further for 18 hours. After the completion of the reaction, the solvent was distilled off under reduced pressure, the resiudue was dissolved in 100 mL of ethyl acetate, washed with 50 mL of water, then dehydrated with and dried over saturated sodium chloride aqueous solution and then anhydrous sodium sulfate, and the solvent was distilled off under reduced pressure to obtain 1.0 g of the aimed product as pale yellow crystal.

1. temperatureunder cooling with ice
2. additionAfter the completion of the addition dropwise
3. stirringto stir further for 18 hours
4. customAfter the completion of the reaction
5. distillationthe solvent was distilled off under reduced pressure
6. dissolutionthe resiudue was dissolved in 100 mL of ethyl acetate
7. washwashed with 50 mL of water
8. dry with materialdried over saturated sodium chloride aqueous solution
9. distillationanhydrous sodium sulfate, and the solvent was distilled off under reduced pressure