反应详情

The reaction mixture of (S)-ethyl 2-(2-bromo-7-hydroxy-5-methylbenzo[d]thiazol-6-yl)-2-tert-butoxyacetate (75A) (380 mg, 0.948 mmol), Selectfluor (1.9 g, 4.74 mmol) in acetonitrile (7 mL) was reacted at 0° C. for 5 days. The reaction mixture was washed by 1.5 M KH2PO4, extracted by EtOAc, the organic phase was dried over MgSO4, filtered, concentrated down and purified by silica gel column, eluting by 0-40% EtOAc in hexanes to give 75B (137 mg, 35%). LCMS-ESI+: calc'd for C16H19FNO4S: 420.0 (M+H+). Found: 420.1 (M+H+).

1. customwas reacted at 0° C. for 5 days
2. washThe reaction mixture was washed by 1.5 M KH2PO4
3. extractionextracted by EtOAc
4. dry with materialthe organic phase was dried over MgSO4
5. filtrationfiltered
6. concentrationconcentrated down
7. custompurified by silica gel column
8. washeluting by 0-40% EtOAc in hexanes