反应详情
EQUATION
反应方程式
REACTANTS
反应物
PRODUCTS
生成物
AUXILIARIES
试剂、催化剂与溶剂
CONDITIONS
反应条件
- 温度
- 50 °C
PROCEDURE
实验过程
To a solution of (S)-ethyl 2-tert-butoxy-2-(7-(4-chlorophenyl)-2-(2-(1,2-dimethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)pyridine-4-yl)-5-methylbenzo[d]thiazol-6-yl)acetate (70 mg, 0.110 mmol) in THF/CH3OH (1.0 mL/1.0 mL) was added 2N NaOH (0.55 mL, 1.1 mmol). The reaction mixture was heated at 50° C. for 2 h and the crude was purified by reverse phase HPLC, eluting by 0-100% acetonitrile in H2O with 0.1% TFA to give the product. LCMS-ESI+: calc'd for C34H31ClN4O3S: 611.2 (M+H+); Found: 612.2 (M+H+), 1H NMR (400 MHz, CD3OD) δ 8.91 (s, 1H), 8.83 (d, J=5.2 Hz, 1H), 8.65 (s, 1H), 8.60 (s, 1H), 8.08 (d, J=5.6 Hz, 1H), 8.04 (s, 1H), 7.80 (d, J=8.8 Hz, 1H), 7.71 (s, 2H), 5.59 (s, 1H), 5.38 (s, 1H), 3.91 (s, 3H), 2.73 (s, 3H), 2.60 (s, 3H), 1.08 (s, 9H).
WORKUP
后处理
- customthe crude was purified by reverse phase HPLC
- washeluting by 0-100% acetonitrile in H2O with 0.1% TFA
- customto give the product