反应详情

(S)-2-tert-butoxy-2-(7-(4-chlorophenyl)-2-(2-(5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)pyridin-4-yl)-5-methylbenzo[d]thiazol-6-yl)acetic acid was prepared in a similar manner as (S)-2-tert-butoxy-2-(7-(4-chlorophenyl)-5-methyl-2-(2-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)pyridin-4-yl)benzo[d]thiazol-6-yl)acetic acid except starting with 5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride instead of 3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride. LCMS-ESI+: calc'd for C30H30ClN6O3S: 589.2 (M+H+); Found: 589.3 (M+H+); 1H NMR (400 MHz, CD3OD) δ 9.11 (s, 1H), 8.28 (d, J=5.4 Hz, 1H), 7.85 (s, 1H), 7.67 (dd, J=8.5, 1.7 Hz, 1H), 7.63-7.51 (m, 4H), 7.34 (d, J=5.3 Hz, 1H), 5.25 (s, 1H), 5.15 (s, 2H), 4.40 (t, J=5.3 Hz, 2H), 4.22 (t, J=5.4 Hz, 2H), 2.60 (s, 3H), 0.96 (s, 9H).