反应详情

Prepared in a manner similar to (S)-ethyl 2-tert-butoxy-2-(7-(4-chlorophenyl)-5-methyl-2-(1-methyl-3-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indazol-6-yl)benzo[d]thiazol-6-yl)acetate except using (S)-ethyl 2-(2-(3-bromo-1-methyl-1H-indazol-5-yl)-7-(4-chlorophenyl)-5-methylbenzo[d]thiazol-6-yl)-2-tert-butoxyacetate instead of (S)-ethyl 2-(2-(3-bromo-1-methyl-1H-indazol-6-yl)-7-(4-chlorophenyl)-5-methylbenzo[d]thiazol-6-yl)-2-tert-butoxyacetate. LCMS-ESI+: calc'd for C36H39ClN4O3S: 643.2, 645.2 (M+H+); Found: 643.1, 645.0 (M+H+). 1H NMR (400 MHz, CD3OD): δ 8.65 (s, 1H), 8.13 (dd, J=8.9, 1.5 Hz, 1H), 7.84 (s, 1H), 7.71 (d, J=8.9 Hz, 1H), 7.65-7.47 (m, 4H), 6.66 (s, 1H), 5.25 (s, 1H), 4.37-4.15 (m, 2H), 4.11 (s, 3H), 4.03-3.87 (m, 2H), 3.87-3.63 (m, 2H), 3.57-3.37 (m, 2H), 3.07 (s, 3H), 2.60 (s, 3H), 1.26 (t, J=7.1 Hz, 3H), 1.00 (s, 9H).