反应详情

Prepared in a similar manner as (S)-2-tert-butoxy-2-(7-(4-chlorophenyl)-5-methyl-2-(1-methyl-3-(1-methylpiperidin-4-yl)-1H-indazol-6-yl)benzo[d]thiazol-6-yl)acetic acid except using (S)-ethyl 2-tert-butoxy-2-(7-(4-chlorophenyl)-5-methyl-2-(1-methyl-3-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indazol-5-yl)benzo[d]thiazol-6-yl)acetate instead of (S)-ethyl 2-tert-butoxy-2-(7-(4-chlorophenyl)-5-methyl-2-(1-methyl-3-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indazol-6-yl)benzo[d]thiazol-6-yl)acetate. LCMS-ESI+: calc'd for C34H37ClN4O3S: 617.2, 619.2 (M+H+); Found: 617.3, 619.2 (M+H+). 1H NMR (400 MHz, CD3OD): δ 8.47 (s, 1H), 8.13 (dd, J=8.9, 1.5 Hz, 1H), 7.83 (s, 1H), 7.74-7.54 (m, 5H), 5.26 (s, 1H), 4.10 (s, 0.3H, minor diastereomer), 4.06 (s, 2.7H, major diastereomer), 3.76-3.60 (m, 2H), 3.58-3.39 (m, 2H), 3.30-3.19 (m, 2H), 2.97 (s, 2.7H, major diastereomer), 2.94 (s, 0.3H, minor diastereomer), 2.63 (s, 3H), 2.49-2.29 (m, 2H), 2.29-2.09 (m, 1H), 0.99 (s, 9H).