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HRID879824

反应详情

EQUATION

反应方程式

HRID 879824 的结构方程式

REACTANTS

反应物

3
结构：O=C(Cl)c1ccccc1
HCID7412

Benzoyl chloride

C7H5ClO

结构：COC(=O)[C@H](Cc1ccc2c(c1)OC[C@H](c1ccc(OCc3ccc(Cl)c(Cl)c3)cc1)O2)NC(=O)OC(C)(C)C
HCID58327295

未命名化合物

结构：COC(=O)[C@@H](N)Cc1ccc(Oc2ccnc(C)c2)cc1.Cl.Cl
HCID66719770

未命名化合物

PRODUCTS

生成物

1
结构：Cc1cc(Oc2ccc(C[C@H](NC(=O)[C@@H]3Cc4cc5c(cc4CN3C(=O)c3ccccc3)O[C@@H](c3ccc(OCc4ccc(Cl)c(Cl)c4)cc3)CO5)C(=O)O)cc2)ccn1
HCID58327456

未命名化合物

PROCEDURE

实验过程

The title compound (24 mg) was prepared from (S)-2-tert-butoxycarbonylamino-3-{(S)-2-[4-(3,4-dichloro-benzyloxy)-phenyl]-2,3-dihydro-benzo[1,4]dioxin-6-yl}-propionic acid methyl ester, which was deprotected according to General Procedure C, subjected to General Procedure V, then acylated with benzoyl chloride according to General Procedure F. Hydrolysis followed General Procedure B and the resulting acid and (S)-2-amino-3-[4-(2-methyl-pyridin-4-yloxy)-phenyl]-propionic acid methyl ester dihydrochloride were reacted according to General Procedures L and B. LCMS (m/z): 845.

WORKUP

后处理

  1. customHydrolysis