反应详情

A solution of 1-(9-methyl-5,7,8,9-tetrahydro-6H-pyrido[3′,4′:4,5]pyrrolo[2,3-b]pyridin-2-yl)-4-(6-(trifluoromethyl)pyridazin-3-yl)pyridin-2(1H)-one (34 mg, 0.081 mmol) in MeOH (2.0 mL) was treated with 1.25 M HCl in MeOH (65 μL, 0.081 mmol), and the resulting solution was stirred at ambient temperature for 3 h. The solution was diluted with Et2O (20 mL), and the resulting solids were collected by filtration to provide the title compound (20 mg, 55%) as a yellow powder: 288-294° C. decomp.; 1H NMR (500 MHz, DMSO-d6) δ 8.72 (d, J=9.0 Hz, 1H), 8.47 (d, J=8.5 Hz, 1H), 8.14 (d, J=7.5 Hz, 1H), 8.06 (d, J=8.5 Hz, 1H), 7.45 (d, J=8.0 Hz, 1H), 7.41 (d, J=2.0 Hz, 1H), 7.23 (dd, J=7.5, 2.0 Hz, 1H), 4.19 (s, 2H), 3.72 (s, 3H), 3.38 (t, J=5.5 Hz, 2H), 3.00 (t, J=5.5 Hz, 2H); ESI MS m/z 427 [M+H]+; HPLC (Method A)>99% (AUC), tR=12.5 min.

1. filtrationthe resulting solids were collected by filtration