反应详情

The product from Example 9c (131 mg, 0.530 mmol) was reacted with the product from Example 8f (97 mg, 0.503 mmol) for 21 h following the procedure from Example 7g giving the title compound as a hydrochloride salt which was triturated with 5:1 ether/THF giving (210 mg, 98%). 1H NMR (300 MHz, DMSO-d6) δ ppm: 1.37 (t, J=7.35 Hz, 3 H) 2.33 (s, 3 H) 3.05 (q, J=7.35 Hz, 2 H) 6.29 (d, J=6.99 Hz, 1 H) 6.74 (d, J=8.46 Hz, 2 H) 7.00 (m, 1 H) 7.17-7.29 (m, 4 H) 7.84 (d, J=8.83 Hz, 1 H) 8.43 (d, J=6.98 Hz, 1 H) 9.09 (d, J=8.83 Hz, 1 H) 9.90 (s, 1 H) 11.12 (br s, 1 H) 14.38 (br s, 1 H); MS (ESI+) m/z 388 (M-Cl)+; (ESI−) m/z 386 (M−HCl)−.