反应详情

A solution of the product of Example 59B (203.7 mg, 0.502 mmol) in anhydrous tetrahydrofuran (4 mL) at −20° under a nitrogen atmosphere was treated with a 1M solution of tetrabutylammonium fluoride in tetrahydrofuran (0.552 mL, 0.552 mmol) and the reaction stirred at −20° for 15 minutes. The reaction was diluted with ethyl acetate (50 mL) and washed with water (2×25 mL) and brine (25 mL). The organic was dried over anhydrous magnesium sulfate, filtered, and concentrated by rotary evaporation under vacuum to provide a yellow oil. Purification by silica gel flash chromatography using 5% ethyl acetate/hexanes as eluent afforded the title compound (42 mg, 33%).

1. washwashed with water (2×25 mL) and brine (25 mL)
2. dry with materialThe organic was dried over anhydrous magnesium sulfate
3. filtrationfiltered
4. concentrationconcentrated by rotary evaporation under vacuum
5. customto provide a yellow oil
6. customPurification by silica gel flash chromatography