反应详情

温度

100 °C

To (4-fluoro-3-trifluoromethyl-benzyl)-(1-methyl-1H-benzimidazol-2-yl)-amine (195 mg, 0.6 mmol) in anhydrous pyridine (3 mL) at room temperature was added benzenesulfonyl chloride (193 mg, 1.1 mmol). The resulting mixture was heated to 100° C. in a microwave reactor for 1 h; then diluted with EtOAc, washed with 1 N HCl, the organic layer was dried over Na2SO4, filtered, and concentrated in vacuo. The resultant residue was purified by flash column chromatography (SiO2), eluting with a hexanes-EtOAc gradient to yield the title compound. MS 464 (M+1)+

1. washwashed with 1 N HCl
2. dry with materialthe organic layer was dried over Na2SO4
3. filtrationfiltered
4. concentrationconcentrated in vacuo
5. customThe resultant residue was purified by flash column chromatography (SiO2)
6. washeluting with a hexanes-EtOAc gradient