反应详情

C7 was prepared in a manner similar to that described in for making C3 in Step 3 of Example 1 except that 4-aminobenzyl alcohol (2.4 g, 19 mmol) was used instead of C2. When the reaction was complete the reaction mixture was concentrated and dissolved in EtOA. The resultant solution was washed with water, brine, dried over MgSO4, and concentrated. The resultant tan solid was triterated with ether and a small amount of EtOAc, filtered and concentrated to provide C7 as a tan solid. Yield: 2.98 g, 50%. MS+ 304.1. 1H NMR (500 MHz, d6-DMSO) δ: 10.61 (s, 1H), 8.76 (s, 1H), 7.59 (d, 2H), 7.26 (d, 2H), 5.10 (bs, 1H), 4.43 (s, 2H).

1. customC7 was prepared in a manner similar to
2. concentrationwas concentrated
3. dissolutiondissolved in EtOA
4. washThe resultant solution was washed with water, brine
5. dry with materialdried over MgSO4
6. concentrationconcentrated
7. filtrationa small amount of EtOAc, filtered
8. concentrationconcentrated