反应详情

A mixture of 2-{4-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl} ethanol (step 450 mg, 1.67 mmol) and bromine (293 mg, 1.83 mmol) in chloroform (10 mL) was stirred at room temperature overnight. The organic solution was washed with 5% aqueous solution sodium thiosulfate, then with brine, and finally dried (Na2SO4) and evaporated. The crude product was purified by TLC with hexane/ethyl acetate (1:1) to afford 451 mg (77%) of the title compound as yellow solids: MS (EI) m/z 348 [M]+, 1H-NMR (CDCl3) δ 7.37 (4H, s), 3.89 (2H, br.s), 2.94 (2H, t, J=6.4 Hz), 2.33 (3H, s).

1. washThe organic solution was washed with 5% aqueous solution sodium thiosulfate
2. dry with materialwith brine, and finally dried (Na2SO4)
3. customevaporated
4. customThe crude product was purified by TLC with hexane/ethyl acetate (1:1)