反应详情

A mixture of 2-[4-(4-iodo-3,5-dimethyl-1H-pyrazol-1-yl)phenyl]ethanol (step 2 of Example 11) (855 mg, 2.5 mmol), 2-tributylstannylthiazole (3 mmol) and tetrakistriphenylophosphinepalladium (346 mg, 0.3 mol) in m-xylene (6 mL) was refluxed for 16 h. The mixture was filtered through a pad of Celite and the filtrate was concentrated. The crude product was purified by TLC with hexane/ethyl acetate (1:1) to afford 39 mg (5%) of the title compound as yellow oil: MS (EI) m/z 299 [M]+.

1. temperaturewas refluxed for 16 h
2. filtrationThe mixture was filtered through a pad of Celite
3. concentrationthe filtrate was concentrated
4. customThe crude product was purified by TLC with hexane/ethyl acetate (1:1)