Phosphorus oxychloride → 1-Chloro-3-methyl-4-isoquinoline acetic acid

HRID 894392Notes

Reaction equation

HRID 894392 reaction equation
[CH3:1][C:2]1[NH:3][C:4](=O)[C:5]2[C:10]([C:11]=1[CH2:12][C:13]([OH:15])=[O:14])=[CH:9][CH:8]=[CH:7][CH:6]=2.P(Cl)(Cl)([Cl:19])=O>C(OCC)(=O)C>[Cl:19][C:4]1[C:5]2[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=2)[C:11]([CH2:12][C:13]([OH:15])=[O:14])=[C:2]([CH3:1])[N:3]=1

Participants

4

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 127155091,2-Dihydro-3-methyl-1-oxo-4-isoquinoline Acetic Acid

Product 1

HCID 127155131-Chloro-3-methyl-4-isoquinoline acetic acid

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

1,2-Dihydro-3-methyl-1-oxo-4-isoquinoline acetic acid (770 mg., 3.30 mmol) and phosphorous oxychloride (1.0 ml. 10.7 mmol) were refluxed in 8 ml. ethyl acetate for 16 hr then vacuum evaporated to dryness. The residue was partitioned between water and ethyl acetate. The aqueous phase was washed with ether. The combined organic phases were washed with brine, dried over magnesium sulfate, filtered, and vacuum evaporated to yield a viscous, homogeneous oil, 1-chloro-3-methyl-4-isoquinoline acetic acid; 772 mg. (99%). This oil (623 mg., 2.65 mmol) in 6 ml. dimethylformamide was added to a solution of 3,4-dichlorobenzyl alcohol (2.75 g., 15.5 mmol) and potassium tert-butoxide (600 mg., 534 mmol) in 2 ml. dimethylformamide and the mixture was heated at 115° for 3 hr. After cooling the mixture was poured onto crushed ice and washed with 3×60 ml. ether. The basic aqueous layer was acidified to pH 3 with 1 N hydrochloric acid and extracted 3×100 ml. ether. The organic extract was dried over magnesium sulfate, filtered, and vacuum evaporated to an oily solid; 568 mg. (57%). Trituration of this residue with methanol then hexane and fractional crystallization from chloroform afforded pure title compound: 44 mg. (4%), mp 180°-183°.

Workup

  1. customvacuum evaporated to dryness
  2. customThe residue was partitioned between water and ethyl acetate
  3. washThe aqueous phase was washed with ether
  4. washThe combined organic phases were washed with brine
  5. dry with materialdried over magnesium sulfate
  6. filtrationfiltered
  7. customvacuum evaporated

Sources & evidence

ORD record
ord-67b25b6b260e4e3c922fd77badf1ce53
Source dataset
uspto-grants-1981_08
Patent number
US04283539

Reaction notes

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