反应详情

A solution of 4.4 g of 8-bromo-2-methylquinoline (20 mmol) in 50 ml of THF was cooled to −78° C., and 8.8 ml of n-BuLi (2.5 M in hexane, 22 mmol) was added dropwise while stirring. After ten minutes of stirring, 3.5 g of 2,3,4,5-tetramethylcyclopentenone (25 mmol) was added dropwise; the solution was heated to room temperature and then heated in reflux for one hour. The solution was cooled down; ice and hydrochloric acid to approximately pH 1 were added; and after neutralization with ammonia solution, the phases were separated and the aqueous phase was extracted with pentane. The combined organic extracts were dried, the pentane was removed in a vacuum, and the remaining brown oil was distilled in a high vacuum (boiling point: 115° C. at 0.01 mbar). A 60% yield (3.2 g) of 1-(2-methyl-8-quinolyl)-2,3,4,5-tetramethylcyclopentadiene in the form of yellow, viscous oil was obtained.

1. stirringAfter ten minutes of stirring
2. temperatureheated
3. temperaturein reflux for one hour
4. temperatureThe solution was cooled down
5. customand after neutralization with ammonia solution, the phases were separated
6. extractionthe aqueous phase was extracted with pentane
7. customThe combined organic extracts were dried
8. customthe pentane was removed in a vacuum
9. distillationthe remaining brown oil was distilled in a high vacuum (boiling point: 115° C. at 0.01 mbar)