HRID898258

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID7498

alpha-Bromotoluene

C7H7Br

结构：CCCN1C(=O)[C@H](CC)N(S(=O)(=O)c2ccc(O)cc2)c2cc(F)ccc21

HCID11538398

未命名化合物

结构：CC[C@H]1C(=O)Nc2ccc(F)cc2N1S(=O)(=O)c1ccc(OC(=O)[O-])cc1

HCID86602729

未命名化合物

PRODUCTS

生成物

结构：CC[C@H]1C(=O)N(Cc2ccccc2)c2ccc(F)cc2N1S(=O)(=O)c1ccc(O)cc1

HCID11619070

未命名化合物

PROCEDURE

实验过程

4-{[(2S)-2-ethyl-7-fluoro-3-oxo-3,4-dihydroquinoxalin-1(2H)-yl]sulfonyl}phenyl carbonate (see Example 20) was treated with benzyl bromide according to the procedure for the preparation of (3S)-3-ethyl-6-fluoro-4-[(4-hydroxyphenyl)sulfonyl]-1-propyl-3,4-dihydroquinoxalin-2(1H)-one (see Example 20) to yield (3S)-1-benzyl-3-ethyl-6-fluoro-4-[(4-hydroxyphenyl)sulfonyl]-3,4-dihydroquinoxalin-2(1H)-one. [α]D25=−30° (c=0.0058 G/ML, DMSO); MS (ESI) m/z 441 ([M+H]+); MS (ESI) m/z 439 ([M−H]−); Anal. Calcd for C23H21FN2O4S: C, 62.71; H, 4.81; N, 6.36. Found: C, 62.23; H, 4.49; N, 6.23.