反应详情

A mixture of 6-chloro-3-methyl-1-propyl-pyrimidine-2,4(1H,3H)-dione (3.76 g), sodium hydrosulphide hydrate (6.0 g) and ethanol (100 ml) was stirred at room temperature for 48 h then concentrated under reduced pressure. The residue was dissolved in water (500 ml) and washed with ethyl acetate (2×100 ml). The aqueous phase was acidified with dilute hydrochloric acid, then extracted with ethyl acetate (3×100 ml). The combined organic phase was dried (MgSO4) and concentrated in vacuo to give a pale yellow solid which was used directly in the next step.

1. concentrationthen concentrated under reduced pressure
2. dissolutionThe residue was dissolved in water (500 ml)
3. washwashed with ethyl acetate (2×100 ml)
4. extractionextracted with ethyl acetate (3×100 ml)
5. dry with materialThe combined organic phase was dried (MgSO4)
6. concentrationconcentrated in vacuo
7. customto give a pale yellow solid which