反应详情

A mixture of 3.08 g (15 mmol) 5-hydroxy-1H-indole-2-carboxylic acid ethyl ester, 2.51 g (20 mmol) 1-isopropyl-3-pyrrolidinol and 8.7 ml (30 mmol) tri-N-butyl phosphine in 75 ml was treated at room temperature with 7.57 g (30 mmol) 1,1′-(azodicarbonyl)-dipiperidine in 75 ml THF. The mixture was allowed to stir for a prolonged period of time and subsequently evaporated to dryness. The residue was suspended in 40 ml DCM/n-heptane 1/1, filtered and again washed with 40 ml DCM/n-heptane 1/1. The filtrate was evaporated and purified on silica eluting with a gradient of DCM/2N NH3 in methanol 99/1 to DCM/2N NH3 in methanol 93/7. The product fractions were evaporated and the residue was titurated with diethyl ether to yield after filtration, washing and drying of the residue at 50° C. under vacuum 2.1 g (44%) of the title compound as off-white solid. MS (m/e): 317.1 (MH+, 100%).

1. customsubsequently evaporated to dryness
2. filtrationfiltered
3. washagain washed with 40 ml DCM/n-heptane 1/1
4. customThe filtrate was evaporated
5. custompurified on silica eluting with a gradient of DCM/2N NH3 in methanol 99/1 to DCM/2N NH3 in methanol 93/7
6. customThe product fractions were evaporated
7. customto yield
8. filtrationafter filtration
9. washwashing
10. dry with materialdrying of the residue at 50° C. under vacuum 2.1 g (44%) of the title compound as off-white solid