反应详情

This compound was prepared from 6-fluoro-2-oxo-4-[4-(furan-2-carbonyl)-piperazine-1-yl]-1,2-dihydro-[1,8]-naphthyridine-3-carbonitrile (99) and benzyl bromide according to General Procedure B. Yield 136 mg (18%), MP 216° C.; 1H-NMR (DMSO-d6): δ 3.72 (m, 4H), 3.95 (m, 4H), 5.53 (s, 2H), 6.66 (dd, J=2.0, 3.6 Hz, 1H), 7.08 (d, J=3.6 Hz, 1H), 7.21-7.28 (m, 5H), 7.89 (d, J=2.0 Hz, 1H), 8.18 (dd, J=2.8, 9.2 Hz, 1H), 8.77 (d, J=2.8 Hz, 1H); EIMS: 458 (M+1). Anal. (C25H20FN5O3) C, H, N.