HRID901350

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CCOC(=O)CC(=O)CC(=O)CCn1c(-c2ccc(F)cc2)c(-c2ccccc2)c(C(=O)Nc2ccccc2)c1C(C)C

HCID11330705

未命名化合物

结构：COC(=O)CC(O)C[C@H](O)CCn1c(-c2ccc(F)cc2)c(-c2ccccc2)c(C(=O)Nc2ccccc2)c1C(C)C

HCID59919136

未命名化合物

PRODUCTS

生成物

结构：CC(C)c1c(C(=O)Nc2ccccc2)c(-c2ccccc2)c(-c2ccc(F)cc2)n1CC[C@@H](O)CC(O)CC(=O)N(C)C

HCID131723631

未命名化合物

PROCEDURE

实验过程

In a process analogous to Step 6 METHOD A, using alternative Ru(II)-chiral diphosphine complexes in place of RuCl2(DMF)n[(R)—Cl—MeO-BIPHEP)] as the hydrogenation catalyst, one can obtain the identical products with varying enantiomeric excess at C-5. For example, in the reduction of 7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-phenylcarbamoyl-pyrrol-1-yl]-3,5-dioxo-heptanoic acid, ethyl ester to (5R)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-phenylcarbamoyl-pyrrol-1-yl]-3,5-dihydroxy-heptanoic acid, methyl ester proceeded as follows:

WORKUP

后处理

customcan obtain the identical products

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-fbb68f6533c142269cd3a26748c54457
来源数据集: uspto-grants-2008_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07361771B2
来源说明: uspto-grants-2008_04

反应 SMILES

[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:9]([CH2:31][CH2:32][C:33](=[O:43])[CH2:34][C:35](=[O:42])[CH2:36][C:37]([O:39]CC)=O)[C:10]([CH:28]([CH3:30])[CH3:29])=[C:11]([C:19](=[O:27])[NH:20][C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)[C:12]=2[C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[CH:4][CH:3]=1.FC1C=CC([C:51]2[N:52](CC[C@@H](O)CC(O)CC(OC)=O)[C:53](C(C)C)=C(C(=O)NC3C=CC=CC=3)C=2C2C=CC=CC=2)=CC=1>>[CH3:51][N:52]([CH3:53])[C:37](=[O:39])[CH2:36][CH:35]([OH:42])[CH2:34][C@H:33]([OH:43])[CH2:32][CH2:31][N:9]1[C:10]([CH:28]([CH3:30])[CH3:29])=[C:11]([C:19](=[O:27])[NH:20][C:21]2[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=2)[C:12]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[C:8]1[C:5]1[CH:4]=[CH:3][C:2]([F:1])=[CH:7][CH:6]=1