反应详情

Benzhydrylidene-[6-methyl-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazin-2-yl]-amine (0.158 g, 0.357 mmol), NaOAc (70 mg, 0.857 mmol) and NH2OH HCl (45 mg, 0.643 mmol) were dissolved in MeOH (4 mL) and stirred at RT overnight, and partitioned between EtOAc and brine. The organic layer was dried (MgSO4), filtered, concentrated, and purified by SiO2 chromatography (24 g SiO2, hexanes/EtOAc 0-90% EtOAc) to give 58 mg of 6-methyl-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazin-2-ylamine as a yellow solid (58% yield).

1. custompartitioned between EtOAc and brine
2. dry with materialThe organic layer was dried (MgSO4)
3. filtrationfiltered
4. concentrationconcentrated
5. custompurified by SiO2 chromatography (24 g SiO2, hexanes/EtOAc 0-90% EtOAc)