Pinacol → 1-(oxan-2-yl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

Temperature

-90 °C

A solution of butyllithium (18.17 ml, 2.5M in hexanes) was added to 4-bromo-1-tetrahydropyran-2-yl-pyrazole, in solution in THF (400 ml) between −100° C. and −80° C. under nitrogen atmosphere. The mixture was stirred for 1 hour at −90° C. Trimethoxyborane (5.07 ml) was added at −70° C. and the mixture was stirred for a further 30 minutes. The mixture was quenched with a 15% solution of ammonium chloride (5 ml); the mixture was allowed to warm to room temperature and was stirred for 30 minutes. The organic layer was separated and the aqueous layer was extracted with 20 ml of THF. The combined organic portions were dried over magnesium sulphate and the solvent was evaporated under reduce pressure to afford the crude boronic acid. 2,3-dimethylbutane-2,3-diol (5.11 g) was added to the boronic acid in solution in THF with 4 A molecular sieves (100 mg). The mixture was stirred at room temperature for 15 hours. The mixture was evaporated under reduce pressure. Water (5 ml) was added and the mixture was extracted with heptane (3×10 ml), dried over magnesium sulphate, filtered and evaporated under reduce pressure to afford 1-tetrahydropyran-2-yl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole (8.80 g). NMR Spectrum: (CDCl3) 1.31 (s, 1H), 1.54-1.76 (m, 4H), 1.95-2.17 (m, 2H), 3.66-3.73 (m, 1H), 4.01-4.07 (m, 1H), 5.41 (dd, 1H), 7.82 (s, 1H), 7.94 (s, 1H)

1. stirringthe mixture was stirred for a further 30 minutes
2. customThe mixture was quenched with a 15% solution of ammonium chloride (5 ml)
3. temperatureto warm to room temperature
4. stirringwas stirred for 30 minutes
5. customThe organic layer was separated
6. extractionthe aqueous layer was extracted with 20 ml of THF
7. dry with materialThe combined organic portions were dried over magnesium sulphate
8. customthe solvent was evaporated
9. customto afford the crude boronic acid
10. stirringThe mixture was stirred at room temperature for 15 hours
11. customThe mixture was evaporated
12. additionWater (5 ml) was added
13. extractionthe mixture was extracted with heptane (3×10 ml)
14. dry with materialdried over magnesium sulphate
15. filtrationfiltered
16. customevaporated

ORD record

ord-9a9e30116f354dfdb5eadaa629a1873f

Source dataset

uspto-grants-2011_09

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08017611B2