反应详情

Using analogous procedures to those described in Example 17, tert-butyl 4-[4-[5-amino-6-(6-fluoro-1,3-benzoxazol-2-yl)pyrazin-2-yl]pyrazol-1-yl]piperidine-1-carboxylate (100 mg) was reacted with TFA to give 3-(6-fluoro-1,3-benzoxazol-2-yl)-5-[1-(4-piperidyl)pyrazol-4-yl]pyrazin-2-amine (46 mg). NMR Spectrum: (400 MHz, MeOD) 8.60 (s, 1H), 8.35 (s, 1H), 8.20 (s, 1H), 7.90 (dd, 1H), 7.60 (dd, 1H), 7.30 (dd, 1H), 4.20 (m, 1H), 3.70 (m, 1H), 3.30 (m, 2H), 2.50 (m, 4H); Mass spectrum: M+H+ 380