反应详情

To a solution of the compound (50 mg) obtained in Step 6 in pyridine (0.5 ml) was added, with stirring at room temperature, 2-fluoro-4-trifluoromethoxybenzenesulfonyl chloride (46 mg). After stirring overnight at room temperature, the reaction mixture was concentrated under reduced pressure. The residue was partitioned by adding ethyl acetate and water. The organic layer was washed successively with 1N aqueous hydrochloric acid solution, saturated aqueous sodium hydrogen carbonate solution and saturated brine, dried over anhydrous magnesium sulfate, filtrated, and concentrated under reduced pressure. The residue was purified by thin layer chromatography (ethyl acetate:n-hexane=1:2) to give the title compound (59 mg).

1. stirringAfter stirring overnight at room temperature
2. concentrationthe reaction mixture was concentrated under reduced pressure
3. customThe residue was partitioned
4. additionby adding ethyl acetate and water
5. washThe organic layer was washed successively with 1N aqueous hydrochloric acid solution, saturated aqueous sodium hydrogen carbonate solution and saturated brine
6. dry with materialdried over anhydrous magnesium sulfate
7. filtrationfiltrated
8. concentrationconcentrated under reduced pressure
9. customThe residue was purified by thin layer chromatography (ethyl acetate:n-hexane=1:2)