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0 °C

t-Butyl 2-(1,3-thiazol-2-yl)-1H-pyrrole-1-carboxylate (6.70 g, 26.8 mmol) synthesized in Example (1f) was dissolved in tetrahydrofuran (100 mL) and cooled to 0° C. With stirring under nitrogen atmosphere, N-bromosuccinimide (4.79 g, 26.9 mmol) was divided into 5 parts to be added every 10 minutes, followed by further stirring at 0° C. for 2 hours. A saturated aqueous sodium hydrogencarbonate solution (200 mL) was added, and extraction was carried out with ethyl acetate (300 mL). The organic layer was washed with saturated brine, and subsequently dried over sodium sulfate. The solvent was distilled off under reduced pressure, and the resulting residue was purified using silica gel column chromatography (elution solvent: ethyl acetate/hexane=0%-16%) to afford the desired compound (7.55 g, yield 86%) as a white solid.

1. additionto be added every 10 minutes
2. stirringby further stirring at 0° C. for 2 hours
3. extractionextraction
4. washThe organic layer was washed with saturated brine
5. dry with materialsubsequently dried over sodium sulfate
6. distillationThe solvent was distilled off under reduced pressure
7. customthe resulting residue was purified
8. washsilica gel column chromatography (elution solvent: ethyl acetate/hexane=0%-16%)