反应详情

The subtitled compound (1.03 g) was prepared from tert-butyl 3-(3-bromophenethoxy)propanoate [Preparation 3, Step i)] and 1-isopropyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole [Example 20, Step i)] using a similar method to that described in Example 18, Step i). MS [M+H-C4H9]+=303 (MultiMode+) 1H NMR (400 MHz, CDCl3) δ 7.76 (s, 1H), 7.67 (s, 1H), 7.36-7.23 (m, 3H), 7.07 (d, J=7.4 Hz, 1H), 4.53 (septet, J=6.7 Hz, 1H), 3.70 (t, J=6.5 Hz, 2H), 3.68 (t, J=7.3 Hz, 2H), 2.89 (t, J=7.1 Hz, 2H), 2.49 (t, J=6.5 Hz, 2H), 1.55 (d, J=6.7 Hz, 6H), 1.43 (s, 9H)