反应详情

To a stirred solution of [(3RS,4SR)-1-benzyl-4-(3-chloro-phenyl)-pyrrolidin-3-yl]-methyl-(4-trifluoromethyl-benzyl)-amine (500 mg, 1.09 mmol) in CH3CN (7 ml) at RT, was added 2,2,2-trichloroethyl chloroformate (0.22 ml, 1.63 mmol). The reaction mixture was stirred at RT for 3 hours, concentrated under vacuo. The residue was dissolved in AcOH (5 ml) and zinc dust (200 mg) was added portion wise over 1 hours. The solvent was evaporated, the residue diluted in EtOAc and the organic phase was washed with an aqueous solution of NaHCO3. The organic phase was dried over Na2SO4 and concentrated under vacuo. The product was purified by column chromatography (CH2Cl2/MeOH: 9/1) to afford 305 mg (76%) of the tile compound as a colorless oil. ES-MS m/e: 369.2 (M+H+).

1. concentrationconcentrated under vacuo
2. dissolutionThe residue was dissolved in AcOH (5 ml)
3. additionzinc dust (200 mg) was added portion wise over 1 hours
4. customThe solvent was evaporated
5. additionthe residue diluted in EtOAc
6. washthe organic phase was washed with an aqueous solution of NaHCO3
7. dry with materialThe organic phase was dried over Na2SO4
8. concentrationconcentrated under vacuo
9. customThe product was purified by column chromatography (CH2Cl2/MeOH: 9/1)