Hydrochloric Acid → HCID 178431958, compound

HRID 910890Notes

Reaction equation

HRID 910890 reaction equation
C([O:8][C:9]1[CH:14]=[CH:13][N:12]=[C:11]([NH:15][C:16]2[S:17][CH:18]=[C:19]([CH3:21])[N:20]=2)[CH:10]=1)C1C=CC=CC=1.Cl>>[CH3:21][C:19]1[N:20]=[C:16]([NH:15][C:11]2[CH:10]=[C:9]([OH:8])[CH:14]=[CH:13][N:12]=2)[S:17][CH:18]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 866347144-(benzyloxy)-N-(4-methylthiazol-2-yl)pyridin-2-amine

Product 1

HCID 178431958HCID 178431958, compoundYield 38.7%

Procedure

Following the method of Example 3, Step A, 4-(benzyloxy)-N-(4-methylthiazol-2-yl)pyridin-2-amine (prepared according to Example 17) (2.3 g, 7.73 mmol), and HCl (38.7 mL, 116 mmol) (3M HCl) were reacted to provide 2-(4-methylthiazol-2-ylamino)pyridin-4-ol (0.620 g, 38.7% yield) as white solid. 1H NMR (CDCl3) δ 7.38 (bs, 1H), 6.23 (m, 2H), 6.10 (bs, 1H), 2.28 (s, 3H). HPLC (5 to 95) Rt=1.82 min; Mass spectrum (esi) m/z=208 (M+H).

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-f5a011ecc1e64efb878d0c77616b852f
Source dataset
uspto-grants-2011_09
Patent number
US08022222B2

Reaction notes

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