反应详情

Ethyl 3-(2-(3-benzoylthioureido)-5-bromopyridin-3-yloxy)-4-chlorobenzoate (8.05 g, 15.1 mmol) and K2CO3 (10.4 g, 75.3 mmol) were placed in ethanol (150 mL) and heated to reflux for 2 days and then cooled. The reaction mixture was filtered and the filtrate was concentrated, triturated with water, and dried. The remaining solid was dissolved in CH2Cl2 and purified by silica gel chromatography to give ethyl 3-(5-bromo-2-thioureidopyridin-3-yloxy)-4-chlorobenzoate (1.70 g, 26.2% yield).

1. temperatureheated
2. temperatureto reflux for 2 days
3. temperaturecooled
4. filtrationThe reaction mixture was filtered
5. concentrationthe filtrate was concentrated
6. customtriturated with water
7. customdried
8. dissolutionThe remaining solid was dissolved in CH2Cl2
9. custompurified by silica gel chromatography