反应详情

A solution of N-{4-chloro-3-(trifluoromethyl)-2-[(trimethylsilyl)ethynyl]phenyl}-2,2-dimethylpropanamide (Example 60B) in THF (10 mL) was treated with TBAF (3.2 mL, 1 M in THF, 3 equiv) and the reaction mixture was left to stir at ambient temperature for 14 h. Concentration was followed by partitioning between EtOAc and water. The organic portion was dried (Na2SO4), filtered, and concentrated to a waxy yellow solid. This material was used for the next reaction without further purification: MS (ESI): m/z 218 (M−1).

1. waitthe reaction mixture was left
2. concentrationConcentration
3. customby partitioning between EtOAc and water
4. dry with materialThe organic portion was dried (Na2SO4)
5. filtrationfiltered
6. concentrationconcentrated to a waxy yellow solid
7. customThis material was used for the next reaction without further purification