反应详情

The title compound was synthesized from 4-(9-cyclohexyl-7,7-difluoro-5-methyl-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[5,4-b][1,4]diazepin-2-ylamino)-3-methoxybenzoic acid as described in the General procedure for amide bond synthesis using HATU and piperidin-1-amine. The final compound was purified by reverse phase HPLC and basified to give the free base. 1H NMR (400 MHz, DMSO-d6) δ ppm 1.15-1.90 (m, 16H) 3.16 (br. s., 6H) 3.32 (s, 3H) 3.96 (s, 3H) 4.14 (t, 2H) 4.48 (quin, 1H) 7.47 (d, 1H) 7.49 (s, 1H) 8.22 (d, 1H) 8.24 (s, 1H) 8.47 (br. s., 1H). [M+H] calc'd for C27H35F2N7O3 544. found 544.

1. customas described in the General procedure for amide bond synthesis
2. customThe final compound was purified by reverse phase HPLC
3. customto give the free base