反应详情

The title compound was synthesized from 4-(9-cyclopentyl-7-ethyl-7-fluoro-5-methyl-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[5,4-b][1,4]diazepin-2-ylamino)-3-methoxybenzoic acid as described in the General procedure for amide bond synthesis using HATU and. 1-methylpiperidin-4-amine. The final compound was purified by reverse phase HPLC and basified to give the free base. 1H NMR (400 MHz, DMSO-d6) δ ppm 0.89 (t, J=7.3 Hz, 3H) 1.60-1.75 (m, 11H) 1.84-2.09 (m, 5H) 2.19 (s, 3H) 2.80 (d, J=11.1 Hz, 2H) 3.26 (s, 3H) 3.60-3.83 (m, 3H) 3.94 (s, 3H) 4.78 (t, J=8.1 Hz, 1H) 7.35-7.60 (m, 2H) 7.80 (s, 1H) 8.08 (d, J=7.6 Hz, 1H) 8.16 (s, 1H) 8.32 (d, J=8.3 Hz, 1H). Melting point: 149-153° C. [M+H] calc'd for C29H40FN7O3, 554. found 554.

1. customas described in the General procedure for amide bond synthesis
2. customThe final compound was purified by reverse phase HPLC
3. customto give the free base