反应详情

The title compound was synthesized from 4-(9-cyclopentyl-7-ethyl-7-fluoro-5-methyl-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[5,4-b][1,4]diazepin-2-ylamino)-3-methoxybenzoic acid as described in the General procedure for amide bond synthesis using HATU and 1-methylazetidin-3-amine hydrochloride. The final compound was purified by reverse phase HPLC and basified to give the free base. 1H NMR (400 MHz, DMSO-d6) δ ppm 0.89 (t, J=7.3 Hz, 3H) 1.6-1.87 (m, 7H) 1.89-1.99 (m, 3H) 2.29 (s, 3H) 3.04 (t, J=7.1 Hz, 2H) 3.27 (s, 3H) 3.59 (t, J=7.2 Hz, 2H) 3.64-3.87 (m, 2H) 3.95 (s, 3H) 4.29-4.53 (m, 1H) 4.79 (t, J=8.1 Hz, 1H) 7.42-7.59 (m, 2H) 7.82 (s, 1H) 8.17 (s, 1H) 8.34 (d, J=8.3 Hz, 1H) 8.61 (d, J=6.8 Hz, 1H). [M+H] calc'd for C27H36FN7O3, 526. found 526.

1. customas described in the General procedure for amide bond synthesis
2. customThe final compound was purified by reverse phase HPLC
3. customto give the free base