反应详情

Subsequently, ((1-naphthyl)methyl)(2-amino-4-methyl-phenyl)amine (943.1 mg, 3.59 mmol) was dissolved in ethanol (6.4 ml), to which carbon bisulfide (7 ml, 116 mmol) was added, and then refluxed. After 10 hours, it was returned to room temperature, concentrated under reduced pressure. Ethanol (2 ml) was added to the residue, which was stirred at room temperature for 30 minutes, and was further stirred on ice for 30 minutes. The resulting crystals were filtered, and dried to obtain 1-((1-naphthyl)methyl)-6-methyl-benzimidazole-2-thiol (459.1 mg, yield 44%, 2 steps).

1. additionwas added
2. temperaturerefluxed
3. customwas returned to room temperature
4. concentrationconcentrated under reduced pressure
5. additionEthanol (2 ml) was added to the residue, which
6. stirringwas further stirred on ice for 30 minutes
7. filtrationThe resulting crystals were filtered
8. customdried