反应详情

To a solution of methyl 6-(2,4-dichlorophenyl)-5-(4-chlorophenyl)pyridine-2-carboxylate (300 mg, 0.76 mmol) from Example 95, Step E in methanol (6 mL) was added 5N sodium hydroxide (0.300 mL, 1.5 mmol). The reaction was stirred at rt for 20 h and was then concentrated in vacuo. The residue was partitioned between methylene chloride and 2N hydrochloric acid. The organic layer was washed with brine, dried over sodium sulfate, and evaporated to give the crude title compound as a yellow foam. HPLC/MS: 378 (M+1), 380 (M+3); Rt=3.73 min

1. concentrationwas then concentrated in vacuo
2. customThe residue was partitioned between methylene chloride and 2N hydrochloric acid
3. washThe organic layer was washed with brine
4. dry with materialdried over sodium sulfate
5. customevaporated